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Urokinase

Also known as Abbokinase and Kinlytic

Urokinase (trade name Abbokinase), also called urokinase-type plasminogen activator (uPA), is a serine protease (EC 3.4.21.73). It was first discovered in 1947 by McFarlane. ( Nursing grand rounds pdfs.journals.lww.com/.../Nursing_grand_rounds.8.pdf J Vitello-Cicciu - 1987 ). Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolysis cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer.

Source: Wikipedia

What is it prescribed for?

Patients are most commonly prescribed urokinase to treat blastomycosis, rabies, west nile virus, and pick disease.

What drug interactions are known?

Do not take urokinase if you are taking any of the following:

Critical Interactions


Significant Interactions

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