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Streptokinase

Also known as Kabikinase and Streptase

Streptokinase (SK), a protein secreted by several species of streptococci can bind and activate human plasminogen. SK is used as an effective and inexpensive thrombolysis medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. Streptokinase belongs to a group of medications known as fibrinolytics, and complexes of streptokinase with human plasminogen can hydrolytically activate other unbound plasminogen by activating through bond cleavage to produce plasmin. There are three domains to Streptokinase, denoted α (residues 1–150), β (residues 151–287), and γ (residues 288–414). Each domain binds plasminogen, although none can activate plasminogen independently.

Source: Wikipedia

What is it prescribed for?

Patients are most commonly prescribed streptokinase to treat rabies, blastomycosis, west nile virus, and pick disease.

What drug interactions are known?

Do not take streptokinase if you are taking any of the following:

Critical Interactions


Significant Interactions

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