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Orphenadrine (Flexon)

Also known as Norgesic, Orphengesic, Biorphen, Disipal, Banflex, Flexoject, Flexon, Mio-Rel, Myolin, and Orfro


Orphenadrine (sold under the brand names: Norflex, Mephenamin, Disipal, Banflex, Flexon, Biorphen, Brocasipal, Dolan, Norgesic, OrfenAce and others) is an anticholinergic drug of the ethanolamine antihistamine class with prominent CNS and peripheral actions used to treat painful muscle spasms, other similar conditions, as well as the treatment of some aspects of Parkinson's Disease. It is closely related to diphenhydramine. Therefore, it is related to other drugs used for Parkinson's like benztropine and trihexyphenidyl, and it is also structurally related to nefopam, which is a centrally-acting yet non-opioid analgesic. The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including pain from: radiculopathy, muscle pain, and headaches. Orphenadrine has approximately 58% of the anticholinergic potency of atropine at equivalent doses.

Source: Wikipedia

DEA Class 4 meaning a low potential for abuse and low risk of dependence.

Estimated Total Cost: $37.48 for an average of 21 days supply

What is it prescribed for?

Patients are most commonly prescribed orphenadrine to treat sprain or strain, back pain, lumbago, and low back pain.

What drug interactions are known?

Do not take orphenadrine if you are taking any of the following:

Critical Interactions

Significant Interactions


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