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Ondansetron (Zofran)

Also known as Zofran and Zuplenz


Ondansetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic (to treat nausea and vomiting), often following chemotherapy. It affects both peripheral and central nerves. Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.

Source: Wikipedia

Estimated Total Cost: $76.33 for an average of 14 days supply

What is it prescribed for?

Patients are most commonly prescribed ondansetron to treat vomiting, nausea, noninfectious gastroenteritis, and hyperemesis gravidarum.

What drug interactions are known?

Do not take ondansetron if you are taking any of the following:

Critical Interactions


Significant Interactions

What side effects are related?

Patients taking ondansetron most commonly experience side effects like sleepiness, headache, and constipation.

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