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Diphenoxylate (Lomotil)

Also known as Lomotil, Di-Atro, Dimotal, Lomocot, Lonox, and Vi-Atro


Diphenoxylate (R-1132) is an opioid agonist used for the treatment of diarrhea that acts by slowing intestinal contractions and peristalsis allowing the body to consolidate intestinal contents and prolong transit time, thus allowing the intestines to draw moisture out of them at a normal or higher rate and therefore stop the formation of loose and liquid stools. It is the main active ingredient in the anti-peristaltic medication Lomotil, which also contains atropine as noted below.

Source: Wikipedia

What is it prescribed for?

Patients are most commonly prescribed diphenoxylate to treat diarrhea, vomiting, human immunodeficiency virus infection (hiv), and rabies.

What drug interactions are known?

Do not take diphenoxylate if you are taking any of the following:

Critical Interactions

Significant Interactions


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