Also known as Clozaril, Ivax Brand Of Clozapine, and Fazaclo
Clozapine is an atypical antipsychotic medication used in the treatment of schizophrenia, and is also sometimes used off-label for the treatment of bipolar disorder. The first of the atypical antipsychotics to be developed, it was first introduced in Europe in 1971, but was voluntarily withdrawn by the manufacturer in 1975 after it was shown to cause agranulocytosis, a condition involving a dangerous decrease in the number of white blood cells, that led to death in some patients. In 1989 after studies demonstrated that it was effective in treating treatment-resistant schizophrenia the United States Food and Drug Administration (FDA) approved the use of clozapine solely for that use, requiring regular white blood cell and absolute neutrophil counts. The FDA also requires clozapine to carry five black box warnings for agranulocytosis, seizures, myocarditis, for "other adverse cardiovascular and respiratory effects", and for "increased mortality in elderly patients with dementia-related psychosis." In 2002 the FDA approved clozapine for reducing the risk of suicidal behavior for patients with schizophrenia.Source: Wikipedia
Estimated Total Cost: $137.31 for an average of 21 days supply
Patients are most commonly prescribed clozapine to treat schizophrenia, psychotic disorder, delusions or hallucinations, and obsessive compulsive disorder (ocd).
Patients taking clozapine most commonly experience side effects like sleepiness, increased heart rate, and constipation.
|Increased heart rate|
|High blood pressure|
|Shortness of breath|
|Muscle cramps, contractures, or spasms|
|Incontinence of stool|
|Retention of urine|
|Congenital heart defect|