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Syphilis

Also known as Lues and Luetic Disease

Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum subspecies pallidum. The primary route of transmission is through sexual contact; it may also be transmitted from mother to fetus during pregnancy or at birth, resulting in congenital syphilis. Other human diseases caused by related Treponema pallidum include yaws (subspecies pertenue), pinta (subspecies carateum), and bejel (subspecies endemicum).

Source: Wikipedia

What are the symptoms?

Within all the people who go to their doctor with syphilis, 50% report having skin rash, 34% report having headache, and 17% report having foot or toe swelling. The symptoms that are highly suggestive of syphilis are arm lump or mass and muscle weakness, although you may still have syphilis without those symptoms.


What might my doctor prescribe?

Common Tests and Procedures

Patients with syphilis often receive hematologic tests, complete physical skin exam performed (ml), urinalysis, glucose measurement, wound care management, chlamydia test, examination of breast and lipid panel .

Common Medications

The most commonly prescribed drugs for patients with syphilis include penicillin, emtricitabine-tenofovir, ritonavir (norvir), tenofovir, lamivudine, diclofenac / misoprostol, efavirenz/emtricitabine/tenofovir, cyclophosphamide, kaletra, palonosetron (aloxi), atazanavir (reyataz), fosinopril and loperamide (imodium) .

Penicillin

Emtricitabine-Tenofovir

Ritonavir (Norvir)
$345
(28 days)
Tenofovir

Lamivudine
$292
(28 days)
Cyclophosphamide
$127
(28 days)
Kaletra
$693
(28 days)
Palonosetron (Aloxi)
$733
(21 days)
Atazanavir (Reyataz)
$880
(28 days)
Fosinopril
$15
(28 days)
Loperamide (Imodium)
$8
(14 days)

Who is at risk?

Groups of people at highest risk for syphilis include age 30-44 years race/ethnicity = black.

Age

< 1 years
0.6x
1-4 years
0.2x
5-14 years
0.1x
15-29 years
0.8x
30-44 years
1.6x
45-59 years
1.5x
60-74 years
1.1x
75+ years
0.6x

Sex

Male
1.3x
Female
0.8x

Race/Ethnicity

Black
1.6x
Hispanic
1.5x
White
0.7x
Other
0.8x
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