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Sickle cell crisis

Also known as Sickle Cell Pain Crisis

Sickle-cell disease (SCD), or sickle-cell anaemia (SCA) or drepanocytosis, is a hereditary blood disorder, characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various complications. The sickling occurs because of a mutation in the haemoglobin gene. Individuals with one copy of the defunct gene display both normal and abnormal haemoglobin. This is an example of codominance.

Source: Wikipedia

What are the symptoms?

Within all the people who go to their doctor with sickle cell crisis, 73% report having ache all over, 71% report having leg pain, and 68% report having back pain. The symptoms that are highly suggestive of sickle cell crisis are ache all over, although you may still have sickle cell crisis without those symptoms.


What might my doctor prescribe?

Common Tests and Procedures

Patients with sickle cell crisis often receive hematologic tests, complete blood count, intravenous fluid replacement, radiographic imaging procedure, plain x-ray, kidney function tests, electrolytes panel and glucose measurement .

Common Medications

The most commonly prescribed drugs for patients with sickle cell crisis include hydromorphone (dilaudid), diphenhydramine (benadryl), morphine (rms), folic acid, meperidine (demerol), hydroxyurea, lvp solution, magaldrate, potassium bicarbonate, scopolamine, buprenorphine (suboxone), cefotaxime and meperidine / promethazine .

Hydromorphone (Dilaudid)
$50
(21 days)
Diphenhydramine (Benadryl)
$5
(21 days)
Morphine (Rms)
$89
(28 days)
Folic Acid
$3
(28 days)
Meperidine (Demerol)
$27
(14 days)
Hydroxyurea
$27
(28 days)
Lvp Solution

Magaldrate

Potassium Bicarbonate
$12
(28 days)
Scopolamine
$51
(14 days)
Buprenorphine (Suboxone)
$326
(21 days)
Cefotaxime
$147
(7 days)

Who is at risk?

Groups of people at highest risk for sickle cell crisis include age 30-44 years, race/ethnicity = black and age 15-29 years. On the other hand, age 75+ years, age 60-74 years, and race/ethnicity = white almost never get sickle cell crisis.

Age

< 1 years
0.2x
1-4 years
0.3x
5-14 years
1.1x
15-29 years
2.6x
30-44 years
1.6x
45-59 years
0.3x
60-74 years
0.0x
75+ years
0.0x

Sex

Male
1.2x
Female
0.9x

Race/Ethnicity

Black
4.7x
Hispanic
0.4x
White
0.0x
Other
0.2x
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