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Premature ovarian failure

Premature Ovarian Failure (POF), also known as premature ovarian insufficiency, primary ovarian insufficiency (this is the most accurate term as some women may still conceive), premature menopause, hypergonadotropic hypogonadism, is the loss of function of the ovaries before age 40. A commonly cited triad for the diagnosis is amenorrhea, hypergonadotropinism, and hypoestrogenism. If it has a genetic cause, it may be called gonadal dysgenesis

Source: Wikipedia

What are the symptoms?

Within all the people who go to their doctor with premature ovarian failure, 82% report having infertility, 22% report having absence of menstruation, and 22% report having unpredictable menstruation. The symptoms that are highly suggestive of premature ovarian failure are infertility, unpredictable menstruation, absence of menstruation, dry or flaky scalp, and pain during intercourse, although you may still have premature ovarian failure without those symptoms.


What might my doctor prescribe?

Common Tests and Procedures

Patients with premature ovarian failure often receive radiographic imaging procedure, hematologic tests, ultrasonography, pelvis exam, examination of breast, standard pregnancy test, rectal examination and microscopic examination (bacterial smear; culture; toxicology) .

Common Medications

The most commonly prescribed drugs for patients with premature ovarian failure include human chorionic gonadotropin (hcg), clomiphene (clomid), medroxyprogesterone, estradiol, estrogens, conjugated (usp) (premarin), progesterone, leuprolide (lupron), menotropins (hmg), desogestrel / ethinyl estradiol, letrozole (femara), estrogens, conjugated (usp) / medroxyprogesterone, danazol and minoxidil topical .

Who is at risk?

Groups of people at highest risk for premature ovarian failure include race/ethnicity = other, age 30-44 years, sex == female and age 15-29 years. On the other hand, sex == male, age 1-4 years, and age < 1 years almost never get premature ovarian failure.

Age

< 1 years
0.0x
1-4 years
0.0x
5-14 years
0.1x
15-29 years
1.7x
30-44 years
3.2x
45-59 years
0.3x
60-74 years
0.1x
75+ years
0.1x

Sex

Male
0.0x
Female
1.7x

Race/Ethnicity

Black
0.6x
Hispanic
0.5x
White
1.2x
Other
1.7x
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