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Pick disease

Also known as Frontotemporal Dementia

Pick's disease is a rare neurodegenerative disease that causes progressive destruction of nerve cells in the brain. Symptoms include loss of speech (aphasia) and dementia. While some of the symptoms can initially be alleviated, the disease progresses and patients often die within two to ten years. A defining characteristic of the disease is build-up of tau proteins in neurons, accumulating into silver-staining, spherical aggregations known as "Pick bodies".

Source: Wikipedia

What are the symptoms?

Within all the people who go to their doctor with pick disease, 91% report having preoccupation with sex, 91% report having wrist cramps or spasms, and 91% report having joint cramps or spasms. The symptoms that are highly suggestive of pick disease are pain in eye, shoulder cramps or spasms, facial pain, ankle pain, wrist pain, pain during pregnancy, excessive anger, joint stiffness or tightness, pain or soreness of breast, knee lump or mass, fatigue, and excessive urination at night, although you may still have pick disease without those symptoms.


What might my doctor prescribe?

Common Tests and Procedures

Patients with pick disease often receive corneal transplant, transurethral resection of prostate (turp), coronary thrombolysis, control of epistaxis, ct scan abdomen, procedures on spleen, bone marrow transplant and removal of ectopic pregnancy .

Common Medications

The most commonly prescribed drugs for patients with pick disease include chlorpheniramine / phenindamine / phenylpropanolamine, air, mecamylamine, troleandomycin, indium oxyquinoline in-111 (indium in-111 oxyquinoline), pipecuronium (arduan), grepafloxacin (raxar), rabbit anti-human t-lymphocyte globulin (thymoglobulin), iopanoic acid, conjugated estrogens topical, malathion topical, gemtuzumab (mylotarg) and norelgestromin (ortho evra) .

Who is at risk?

Groups of people at highest risk for pick disease include race/ethnicity = other, age 30-44 years, race/ethnicity = hispanic, age 75+ years, age 60-74 years, age 5-14 years, age 1-4 years, race/ethnicity = black, age 15-29 years, age 45-59 years and age < 1 years.

Age

< 1 years
15.5x
1-4 years
8.1x
5-14 years
5.7x
15-29 years
2.6x
30-44 years
2.7x
45-59 years
2.4x
60-74 years
3.5x
75+ years
5.3x

Sex

Male
1.2x
Female
0.9x

Race/Ethnicity

Black
2.6x
Hispanic
3.4x
White
0.8x
Other
9.4x
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