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Paget disease

Also known as Paget Bone Disease and Osteitis Deformans

Sir James Paget, a surgeon and pathologist, described several diseases, including:

Source: Wikipedia

What are the symptoms?

Within all the people who go to their doctor with paget disease, 37% report having ringing in ear, 37% report having delusions or hallucinations, and 37% report having apnea. The symptoms that are highly suggestive of paget disease are abnormal breathing sounds, apnea, sleepiness, ringing in ear, delusions or hallucinations, elbow cramps or spasms, and nailbiting, although you may still have paget disease without those symptoms.


What might my doctor prescribe?

Common Tests and Procedures

Patients with paget disease often receive hematologic tests, complete blood count, bone density scan, sigmoidoscopy or colonoscopy, lipid panel, pelvis exam, microscopic examination (bacterial smear; culture; toxicology) and depression screen .

Common Medications

The most commonly prescribed drugs for patients with paget disease include alendronate, amlodipine, celecoxib (celebrex), risperidone, alfuzosin (uroxatral), timolol, glyburide / metformin, memantine (namenda), colchicine, sennosides, usp (perdiem), hydralazine, finasteride (propecia) and hydrochlorothiazide / lisinopril .

Alendronate

Amlodipine
$10
(28 days)
Celecoxib (Celebrex)
$128
(28 days)
Risperidone
$107
(28 days)
Alfuzosin (Uroxatral)
$98
(28 days)
Timolol
$23
(28 days)
Memantine (Namenda)
$157
(28 days)
Colchicine
$30
(28 days)
Sennosides, Usp (Perdiem)
$9
(28 days)
Hydralazine
$24
(28 days)
Finasteride (Propecia)
$37
(28 days)

Who is at risk?

Groups of people at highest risk for paget disease include age 75+ years race/ethnicity = black. On the other hand, race/ethnicity = other, age 5-14 years, age 1-4 years, and age 15-29 years almost never get paget disease.

Age

< 1 years
0.1x
1-4 years
0.0x
5-14 years
0.0x
15-29 years
0.0x
30-44 years
0.3x
45-59 years
0.8x
60-74 years
1.5x
75+ years
6.1x

Sex

Male
0.5x
Female
1.4x

Race/Ethnicity

Black
1.6x
Hispanic
0.7x
White
1.0x
Other
0.0x
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