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Myasthenia gravis

Also known as MG

Myasthenia gravis (from Greek μύς "muscle", ἀσθένεια "weakness", and Latin: gravis "serious"; abbreviated MG) is an autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatigability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction, inhibiting the excitatory effects of the neurotransmitter acetylcholine on nicotinic receptors throughout neuromuscular junctions.

Source: Wikipedia

What are the symptoms?

Within all the people who go to their doctor with myasthenia gravis, 50% report having double vision, 48% report having weakness, and 36% report having fatigue. The symptoms that are highly suggestive of myasthenia gravis are double vision, abnormal movement of eyelid, focal weakness, slurring words, and arm weakness, although you may still have myasthenia gravis without those symptoms.


What might my doctor prescribe?

Common Tests and Procedures

Patients with myasthenia gravis often receive hematologic tests, other diagnostic procedures (interview; evaluation; consultation), magnetic resonance imaging, hemoglobin a1c measurement, lipid panel, bone density scan, ophthalmic examination and evaluation and microscopic examination (bacterial smear; culture; toxicology) .

Common Medications

The most commonly prescribed drugs for patients with myasthenia gravis include pyridostigmine (mestinon), prednisone, azathioprine, mycophenolate mofetil (cellcept), vitamin b 12, neostigmine, dexamethasone, nabumetone, immunoglobulins, intravenous (gammagard), methimazole, cyclosporine, bumetanide and hyoscyamine (a-spas) .

Pyridostigmine (Mestinon)
$63
(28 days)
Prednisone
$5
(28 days)
Azathioprine
$28
(28 days)
Mycophenolate Mofetil (Cellcept)
$263
(28 days)
Vitamin B 12
$6
(28 days)
Neostigmine
$141
(28 days)
Dexamethasone
$13
(14 days)
Nabumetone
$32
(28 days)
Immunoglobulins, Intravenous (Gammagard)
$5971
(14 days)
Methimazole
$14
(28 days)
Cyclosporine
$209
(28 days)
Bumetanide
$11
(28 days)
Hyoscyamine (A-Spas)
$53
(21 days)

Who is at risk?

Groups of people at highest risk for myasthenia gravis include age 75+ years age 60-74 years.

Age

< 1 years
0.2x
1-4 years
0.1x
5-14 years
0.3x
15-29 years
0.5x
30-44 years
0.8x
45-59 years
1.3x
60-74 years
1.9x
75+ years
1.8x

Sex

Male
1.1x
Female
0.9x

Race/Ethnicity

Black
1.0x
Hispanic
0.6x
White
1.1x
Other
0.4x
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