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Glucocorticoid deficiency

Also known as Addison Disease and Primary Adrenal Insufficiency

Addison’s disease (also chronic adrenal insufficiency, hypocortisolism, and hypoadrenalism) is a rare, chronic endocrine disorder in which the adrenal glands do not produce sufficient steroid hormones (glucocorticoids and often mineralocorticoids). It is characterised by a number of relatively nonspecific symptoms, such as abdominal pain and weakness, but under certain circumstances, these may progress to Addisonian crisis, a severe illness which may include very low blood pressure and coma.

Source: Wikipedia

What are the symptoms?

Within all the people who go to their doctor with glucocorticoid deficiency, 44% report having weakness, 44% report having shortness of breath, and 34% report having problems with movement. The symptoms that are highly suggestive of glucocorticoid deficiency are problems with movement, lack of growth, symptoms of the kidneys, and muscle cramps, contractures, or spasms, although you may still have glucocorticoid deficiency without those symptoms.


What might my doctor prescribe?

Common Tests and Procedures

Patients with glucocorticoid deficiency often receive hematologic tests, complete blood count, urinalysis, intravenous fluid replacement, kidney function tests, glucose measurement, electrocardiogram and electrolytes panel .

Common Medications

The most commonly prescribed drugs for patients with glucocorticoid deficiency include hydrocortisone topical, thyroxine (synthroid), hydrocortisone, fludrocortisone, cosyntropin, ibandronate (boniva), bromocriptine, repaglinide (prandin), quinapril, fexofenadine (allegra), cabergoline, sodium hypochlorite topical and somatropin .

Who is at risk?

Groups of people at highest risk for glucocorticoid deficiency include age 75+ years age 45-59 years. On the other hand, race/ethnicity = other almost never get glucocorticoid deficiency.

Age

< 1 years
0.8x
1-4 years
0.8x
5-14 years
0.3x
15-29 years
0.8x
30-44 years
0.4x
45-59 years
1.8x
60-74 years
1.0x
75+ years
1.8x

Sex

Male
0.9x
Female
1.1x

Race/Ethnicity

Black
0.8x
Hispanic
0.7x
White
1.2x
Other
0.0x
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