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Avascular necrosis

Also known as Ischemic Necrosis and Avascular Necrosis Of Bone

Avascular necrosis (also osteonecrosis, bone infarction, aseptic necrosis, ischemic bone necrosis, and AVN) is a disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply. Without blood, the bone tissue dies and the bone collapses. If avascular necrosis involves the bones of a joint, it often leads to destruction of the joint articular surfaces. (see Osteochondritis dissecans).

Source: Wikipedia

What are the symptoms?

Within all the people who go to their doctor with avascular necrosis, 86% report having hip pain, 53% report having knee pain, and 45% report having shoulder pain. The symptoms that are highly suggestive of avascular necrosis are hip pain, bowlegged or knock-kneed, shoulder stiffness or tightness, and shoulder weakness, although you may still have avascular necrosis without those symptoms.


What might my doctor prescribe?

Common Tests and Procedures

Patients with avascular necrosis often receive radiographic imaging procedure, plain x-ray, complete physical skin exam performed (ml), magnetic resonance imaging, physical therapy exercises, other diagnostic procedures (interview; evaluation; consultation), lipid panel and prostate specific antigen measurement .

Common Medications

The most commonly prescribed drugs for patients with avascular necrosis include oxycodone, emtricitabine-tenofovir, ritonavir (norvir), mycophenolate mofetil (cellcept), hydroxychloroquine (plaquenil), meloxicam, cyclosporine, ropinirole, oxybutynin, bupivacaine, methadone, saquinavir and lopinavir .

Oxycodone
$193
(21 days)
Emtricitabine-Tenofovir

Ritonavir (Norvir)
$345
(28 days)
Mycophenolate Mofetil (Cellcept)
$263
(28 days)
Hydroxychloroquine (Plaquenil)
$17
(28 days)
Meloxicam
$8
(28 days)
Cyclosporine
$209
(28 days)
Ropinirole
$41
(28 days)
Oxybutynin
$37
(28 days)
Bupivacaine
$27
(14 days)
Methadone
$20
(28 days)
Saquinavir
$794
(28 days)
Lopinavir

Who is at risk?

Groups of people at highest risk for avascular necrosis include sex == male age 45-59 years. On the other hand, race/ethnicity = other, age 1-4 years, and age < 1 years almost never get avascular necrosis.

Age

< 1 years
0.0x
1-4 years
0.0x
5-14 years
0.1x
15-29 years
0.7x
30-44 years
1.4x
45-59 years
1.9x
60-74 years
0.8x
75+ years
0.9x

Sex

Male
1.6x
Female
0.6x

Race/Ethnicity

Black
1.4x
Hispanic
0.8x
White
1.0x
Other
0.0x
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